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Tirzepatide shows the lowest discontinuation rates due to adverse events in clinical trials (4-7%), followed closely by semaglutide (approximately 7%)

10.1016/j.addr.2018.07.009 93 ZhangH.WuT.WuY.PengY.WeiX.LuT.et al (2024)

For patients with a history of other cancer types, the decision to use these medications requires individualized assessment

GLP-1 signaling preserves cardiac function in endotoxemic fischer 344 and DPP4-deficient rats

Insurance companies and institutional weight loss programs rarely approve this pairing because of liability and clinical evidence gaps