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Originally developed to treat diabetes, these drugs have become popular for their weight loss efficacy

Their primary mechanisms include: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner Suppressing glucagon release , which reduces hepatic glucose production Slowing gastric emptying , promoting satiety and reducing appetite Acting on central nervous system pathways involved in appetite regulation These combined effects lead to improved glycaemic control in people with type 2 diabetes and significant weight reduction in those with obesity

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The actions of SGLT2 inhibitors on metabolism, renal function and blood pressure

7 In the third case report, tirzepatide for weight loss (a GLP-1/glucose-dependent insulinotropic polypeptide receptor agonist that is available in the United States) had been held for 2 days before their procedure