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Meal timing and structure matter

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Pancreatic -cells initially sense elevated extracellular glucose and allow its cellular entry through the GLUT facilitative glucose transporters [46]

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In support of this, ICV administration of GLP-1 in rats has been shown to attenuate the fasting-induced rise in NPY/AgRP expression and decreases fasting-induced inhibition of POMC/CART expression in the ARC (Seo et al., 2008)

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