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Importantly, semaglutide carries a boxed warning for risk of thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

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At week 16, adjusted mean reduction in HbA1c from baseline was significantly greater with DAPA + SITA + MET ER ( 1.73% [ 19.0 mmol/mol]) compared to SITA + MET SR ( 1.28% [ 14.1 mmol/mol]

The neurons of the iPSC models showed abnormal insulin response and signalling, which resulted in the blockage of neuroprotective pathways and the activation of stress pathways

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