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Details on the statistical analyses of the fMRI data are provided in the Supplemental Methods

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Pre-Meal Timing and Glucose Modulation Administration immediately before meals (within 15 minutes) is critical the 20-minute Tmax must align with the onset of gastric emptying to effectively attenuate the postprandial glucose excursion

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RXFP4, a G protein-coupled receptor (GPCR) with adenylyl cyclase inhibitory function, is located throughout the gastrointestinal tract