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But they tend to be mild. Orlistat has some unique (and unpleasant) side effects, like gas, oily or loose stools, and oily spotting (since your body has to get rid of the excess fat that it's not absorbing)
Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid
Hughes, V
Additionally, when PEN2 is specifically knocked out in the gut, the ability of metformin to promote insulin and GLP-1 secretion is impaired (Ma et al., 2022)
H.CoriddiM.McGrathL.KataruR
