retatrutide diabetes type 2 ESC 2024: improves lipid and cardiovascular risk profile in Phase II trial What is the clinical pharmacology

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What makes Retatrutide different is that instead of mimicking two hormones, it mimics three: GIP, GLP-1, and Glucagon

1 Introduction Type 2 diabetes mellitus (T2DM) is a chronic hyperglycemia-induced metabolic disease ( Glucagon-like Peptide-1 (GLP-1, 3031 aa) is a natural gastrointestinal incretin hormone of the glucagon peptide family, secreted from the enteroendocrine L-cells in the distal gut to stimulate insulin secretion in response to postprandial hyperglycemia (Figure 1)

References 1.Prasad-Reddy L, Isaacs D

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