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Additionally, sclerostin levels were significantly higher in children and lower in adults with PWS compared to controls, indicating that RANK-L, OPG, and sclerostin may play a crucial role in regulating bone turnover in individuals with PWS

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Between June and July 2025, when the formulary change was implemented, switching from AOM tirzepatide increased, while patients with an active supply of AOM semaglutide showed stable or even slightly reduced switching during the same period, consistent with its designation as the preferred option

Difference between groups was analysed by one-way ANOVA followed by the post-hoc Tukey-Kramer test