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While generally safe, its not recommended for: Individuals under 18

Minor amounts are also produced in the L cells of the intestine and certain neurons of the brainstem and hypothalamus

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The gradual titration is designed to allow the body to adjust to GLP-1 receptor activation and minimize gastrointestinal side effects during the initial treatment period

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Compared with baseline, the HbA1c decreased by 1.5% (95% confidence interval [CI], 1.27 to 1.74