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The most commonly reported adverse effects were gastrointestinal in nature , including: Nausea Vomiting Diarrhoea Constipation Decreased appetite These effects were generally mild to moderate in severity, most prevalent during dose escalation, and tended to diminish over time

A large meta-analysis of 64 trials with over 25,500 adults with type 2 diabetes showed that GLP-1s were more effective at reducing A1C levels compared to placebo and traditional diabetes drugs

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How Does Semaglutide Work to Reduce Appetite and Support Weight Loss
