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January 28, 2025

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Linagliptin Effects on Heart Failure and Related Outcomes in Individuals With Type 2 Diabetes Mellitus at High Cardiovascular and Renal Risk in CARMELINA

These gastrointestinal effects are among the most frequently reported and may occur especially during dose escalation

Maximum dose: If additional glycaemic control is needed after at least 30 days on 7 mg, the dose may be increased to 14 mg once daily

Prospective studies and RCTs should be conducted in IBD patients with active inflammation to verify their immunomodulatory effects and assess whether they can be used therapeutically, either alone or as an adjunctive therapy