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Protective MC4R variants identified in the UK Biobank exhibited signaling bias toward -arrestin recruitment and increased MAPK pathway activation suggesting that -arrestin-biased MC4R signaling may represent an effective strategy for weight loss (109, 110)

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Farhan Abdullah is a board-certified Internal Medicine physician and Assistant Professor at UT Southwestern School of Medicine and TCU/UNTHSC School of Medicine who has followed the retatrutide clinical program closely