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1 Background In women, breast cancer (BC) is the most commonly diagnosed cancer and has the second highest mortality rate of all cancers ( Obesity not only increases risk of BC development, predominantly in postmenopausal women, but also confers worse disease outcomes, including greater mortality and shorter time-to-disease recurrence, in both premenopausal and postmenopausal patients with BC ( As with obesity, advanced age is also associated with propagation of systemic and adipose-specific low-grade, chronic inflammation and immune dysfunction ( In light of the biological hallmarks shared between obesity and aging, including chronic inflammation and immune dysfunction ( 2 Methods 2.1 Cell lines E0771 mammary carcinoma cells, purchased from ATCC (#CRL-3461