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78 A statistical analysis that included nine randomized controlled trials, involving a total of 591 women with PCOS, also reported finding omega-3 fatty acid supplementation improved insulin sensitivity, lowered total cholesterol and triglyceride levels, and raised levels of adiponectin (a signaling peptide primarily produced by fat tissue that improves insulin sensitivity and has anti-inflammatory properties)

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The glycine/B12 formulation may offer marginal benefits for muscle preservation, though clinical evidence remains limited

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