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doi: 10.1016/j.tem.2019.07.015 117 StepenskyD.FriedmanM.RazI.HoffmanA

Obesity is associated with abnormalities of the HPO axis

After reading the designated article, the participant should be able to evaluate and use the information appropriately in providing patient care

At the same time, clinicians should closely monitor ketone levels, especially during dose adjustments

Methods Protocol and registration The present systematic review and meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to ensure methodological rigor and transparency

Similar to neurodegenerative disorders and cognitive impairment, metabolic disease and DM are increasing in prevalence globally with the number of individuals with DM at 420 million and expected to reach 700 million individuals in the year 2045