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77 Pharmacological inhibition of PDEs could theoretically sustain or elevate cAMP levels, potentially enhancing GLP-1 RA signaling
It's also important to note that GLP-1 receptor agonists, including semaglutide, carry an FDA-labeled risk of gallbladder disease, which can sometimes present with abnormal liver function tests
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Despite rising heterogeneity between the two included studies due to different patient populations, this confirmed the efficacy of retatrutide in diabetics and nondiabetics
