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Clinical studies have shown that patients using semaglutide in combination with lifestyle modifications can achieve substantial weight loss

Approximately 1% of patients had type 1 diabetes at baseline

However, this is uncommon and linked with concomitant antidiabetic medication administration

There have been different clinical trials conducted on patients with obesity demonstrating the beneficial effect of exercise on metabolic risk factors and liver characteristics

Moreover, promising outcomes from various large-scale cardiovascular outcome trials (CVOTs) have indicated that GLP-1RAs could mitigate the risk of major adverse cardiovascular events (MACE) in T2DM patients with an elevated cardiovascular risk profile (Marso et al., 2016a