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Short-acting GLP-1 RAs such as exenatide BID (Byetta) and lixisenatide (Adlyxin) can significantly delay gastric emptying processes in vivo

Nevertheless, several mouse studies indicate that GLP-1RAs can modulate skeletal muscle metabolism by attenuating obesity-induced muscle atrophy markers via GLP-1 receptor-mediated signaling pathways

Obesity Management. September 2022

An increased risk of malformations was observed for liraglutide and semaglutide at doses comparable to those administered in humans

Obesity (Silver Spring) 19 (1), 121127 (2011)