new glp-1 drug retatrutide Weight loss use requires strict supervision, doctor says How Retatrutide Works

How do GLP-1 receptor agonists affect your body

Although the name can be a bit misleading, Glucagon-Like Peptide-1 agonists (GLP-1s) are diabetes drugs that mimic the natural gut hormone GLP-1, which, unlike glucagon, decreases your blood sugar and reduces glucagon, especially after meals

The SELECT trial demonstrated a 20% reduction in major adverse cardiovascular events in 17,604 adults with preexisting cardiovascular disease, overweight or obesity, without diabetes [1] [2]

Chakhtoura M et al

Both TNF- and MCP-1 promote evolution of atherosclerotic lesions and consequently their deficiency reduce those lesions

CSF IL-6 was also not significantly different in patients with IIH nor were CSF:serum cytokine ratios