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Description
In the real world, it generally involves using doses lower than the established therapeutic amount needed to achieve the intended medical benefit
A simple check: if your concentration is 10 mg/mL and you need 5 mg, your volume should be less than 1 mL

They are laser-focused on medical necessity, not whether your compounded pharmacy is FDA-registered or state-regulated

These are people who gave up hope

The distinction matters because adverse events that are not systematically measured often go underreported in clinical trials
2011;301:R1057
