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The SELECT cardiovascular outcomes trial showed that semaglutide 2.4 mg significantly reduced major adverse cardiovascular events (heart attack, stroke, and cardiovascular death) in patients with established cardiovascular disease and overweight or obesity, even without type 2 diabetes

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These effects are generally transient and tend to be most pronounced during dose escalation, but for many people, digestive changes persist throughout treatment

This article explains GLP-1 weight-loss medications in simple terms and reviews known safety concerns
