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Orforglipron doesn't match tirzepatide's 20% weight loss

For a doctor to prescribe Wegovy your BMI has to be over 30 (or over 27 with a weight-related condition, like high blood pressure or sleep apnea) (5)
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Keep an eye on the retatrutide availability timeline for updates on these newer agents

[cited 2025 Nov 17]
doi: 10.2337/dc13-0465 [DOI] [PMC free article] [PubMed] [Google Scholar] 33
Many plans do cover it, but almost all will require a strict prior authorization process, proving medical necessity with a high BMI and documented failure of other weight loss methods
