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This dual action of stimulating insulin and suppressing glucagon helps lower blood sugar more effectively

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demonstrated that pancreatic, but not intestinal, proglucagon-derived peptides are necessary for the glucoregulatory improvements of DPP-IV inhibitors ( Gcg / mice with selective re-expression of Gcg in the pancreas or the gut revealed a role for pancreatic, but not intestinal, proglucagon products, in the metabolic benefits of vertical sleeve gastrectomy (VSG) (38)