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Novo Nordisks drug officially hit the shelves on Monday, marking its availability despite being greenlit in Canada since 2021

In particular, a randomized controlled trial investigated liraglutide in people with overweight/obesity and knee OA

[7] [8] Because these drugs target distinct pathways in glucose metabolism, they can work synergistically to achieve better diabetes control than either medication alone

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Reports of phase 2 data using 9 mg shows a placebo-adjusted mean weight loss of 15.4% after 24 weeks and 18.6% after 48 weeks (89)

Another limitation is including a pair-fed group to distinguish the direct effects of semaglutide from those resulting from weight loss