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Diabetes impairs hippocampal function via advanced glycation end product mediated new neuron generation in animals with diabetes-related depression

The results show that geniposide can promote ALP activity and mineralization

GLP-1 signaling plays a major role in: inflammation suppression autonomic stability vagalbrain communication metabolic homeostasis neuronal healing If long COVID (in some individuals) is in part a vagal inflammatory disorder , then a class of drugs that directly modulates inflammation and excitability in the nodose ganglion becomes far more relevant than previously realized

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Finally, the exclusion of highrisk populations introduces selection bias, and the likelihood of publication bias, whereby studies reporting favourable outcomes are overrepresented, further constrains the interpretability and clinical applicability of the existing literature