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My clinical takeaway: Dont discontinue GLP-1s reflexively for fear of NAION

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A comprehensive program of nutritional and lifestyle counseling is critical to maximize overall efficacy and improve cost-effectiveness of GLP-1s for obesity.

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Large-scale pharmacoepidemiological data has not demonstrated a statistically significant increase in suicidal behaviour but there are important signals in specific subgroups, particularly those already on antidepressants or benzodiazepines