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In one study examining the effects of combining liraglutide (a GLP-1 drug) with exercise, participants lost more fat and maintained better muscle mass compared to those who used medication alone (Kibenge et al., 2022)

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Some individuals have genetic variants in their GLP-1 receptor gene (such as rs6923761) that affect how powerfully this hormone influences their appetite and glucose control
In her late career, Williams felt her bid for yet more tennis records was compromised by joint issues associated with her weight