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Some patients who stop taking GLP-1s report that their cravings and the weight returns

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Indeed, the fact that administration of phenformin can induce lactic acidosis, while metformin does not, suggests that these two biguanides act through different pathways ( Various in vitro and in vivo studies performed in different types of tumors, highlighted the ability of phenformin to reduce cancer cell proliferation strongly than metformin (Janzer et al., 2014)

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Thats as good as or even better than the GLP-1 agonist medications

Chronic inflammation is a fundamental biological pathway involved in the development and progression of many cancers, said Dr Elizabeth Susan McDonald of the University of Pennsylvania