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The glucagon receptor component introduces a theoretical concern about bone density, as glucagon signalling has been associated with increased bone resorption in some preclinical models

Lancet (2021) 398:14355

Am J Physiol Renal Physiol 310(2):F123F127 Forouhi NG, Wareham NJ (2010) Epidemiology of diabetes
Higher doses (90 mg and 120 mg) achieved up to 12.2% mean reduction from baseline (26.6 lbs) versus 1.3% (2.9 lbs) for placebo, with up to 97% of patients losing 5% of body weight

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