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Barreto-Vianna ARC, Aguila MB, Mandarim-de-Lacerda CA

Small peptides like GLP-1 and GLP-2 are rapidly cleared in vivo , leading to low circulating levels
De Regil, World Health Organization Guideline on the Use and Indications of Glucagon-Like Peptide-1 Therapies for the Treatment of Obesity in Adults, JAMA , Dec

These are the main side effects, but not every potential one
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Even then, most of the older GLP-1 receptor agonists require frequent administration (Table 1) (810)
