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Mutations in the leptin gene leading to congenital leptin deficiency are most often seen in offspring of consanguineous marriages

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Le Glau L, Rouault C, Osinski C, Prifti E, Soula HA, Debdat J, et al

Wood pointed to one large observational study from the U.S

We see Novo Nordisk and Eli Lilly as overvalued despite assuming that a quarter of US adults with obesity will be on GLP-1 therapies by 2031, leading to a GLP-1 market north of $200 billion in 2031, before generic semaglutide (Wegovy/Ozempic/Rybelsus) launches. Competition rises