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Phase 2 NEJM titration (still common in research) Phase 2 retatrutide titration schedule Phase Initiation Weeks Weeks 1-4 Weekly Dose 1 mg Phase Early escalation Weeks Weeks 5-8 Weekly Dose 2 mg Phase Mid escalation Weeks Weeks 9-12 Weekly Dose 4 mg Phase High escalation Weeks Weeks 13-16 Weekly Dose 8 mg Phase Maximum Weeks Weeks 17+ Weekly Dose 12 mg Source: Jastreboff et al., NEJM 2023

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HOLST: I guess I have to emphasize, first of all, that I am a medical doctor, and health and diseases and all that has been on my agenda always for the last 50 years

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Choose from Wegovy, a leading injection-based option for weight management, or its oral counterpart for those with needle aversions