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Additionally, there have been no head-to-head comparisons between the drugs

As noted by experts at the University of Connecticut, GLP-1 peptide molecules are too large to effectively penetrate the skin barrier, making transdermal delivery of actual GLP-1 medications currently impossible with existing technology

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Sleep and Stress Management Poor sleep increases hunger hormones and reduces willpower, potentially counteracting medication effects

Since POMC neurons in the NTS do not express GLP-1Rs [15], Ex-4c administered in vivo might bind and activate arcuate POMC neurons, leading to anorexia