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For a drug to passively diffuse through this layer, it typically needs to be: Small in molecular size Lipophilic (fat-soluble) However, GLP-1 molecules: Are too large and hydrophilic Cannot naturally penetrate the skin barrier Even if GLP-1 patches claim to have GLP-1 drugs, the molecules cannot pass through the skin barrier without support

Laboratory studies can show receptor interactions but cannot fully represent a complete organism

Nakajima et al., 2012

Public Comment Period The FDA opened the proposal for public comment, with the comment period closing June 29, 2026

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