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The most common side effects are gastrointestinal, such as nausea, diarrhea, vomiting, and constipation

The SURPASS program (type 2 diabetes) enrolled more than 19,000 participants across 10 trials

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In that research, participants on the highest dose lost on average 48 pounds over 72 weeks about half a pound per week the kind of gradual progress that's crucial for long-term weight management

Users with hepatic impairment Neither semaglutide nor tirzepatide requires dose adjustment for mild to moderate hepatic impairment