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This complex includes B1, B6, and B12, which are particularly important for maintaining energy levels and reducing fatigue [4]

This inhibition consecutively leads to post-prandial GLP-1 plasma concentrations that are elevated 2-3-fold and mediates the glucose-dependent stimulation of insulin secretion and inhibition of glucagon secretion (Table 1 gives a summary of the clinical phase III studies with at least 52 weeks duration on the efficacy of DPP-4 inhibitors compared to sulfonylureas as add on therapy to metformin, respectively, in patients not reaching their glycaemic goals with a monotherapy of metformin

Enteroendocrine hormones are implicated in a wide range of physiological functions including gastrointestinal motility, appetite control, and glucose homeostasis (10)

Other possible effects include mild constipation, decreased appetite for previously favorite foods, and occasional headaches during the first few days

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