glp-1 agonist and heart failure Receptor Agonists in Impact of GLP-1 receptor agonists

What happens to our relationship with food when hunger is no longer a guide

PMID: 29490085

Pharmacogenomics of GLP-1 receptor agonists: Focus on pharmacological profile

Whole foods such as vegetables, fruits, legumes, whole grains, nuts, seeds, eggs, fish and lean meat tend to be more nutrient-dense and naturally more filling than highly processed foods and help support the natural release of GLP-1 (2)

However, these agents increase risk of intra-operative pulmonary aspiration according to a case report secondary to delayed emptying and presence of gastric residues despite fasting (108, 108) To prevent these events, the recent recommendations from the American Society of Anesthesiology guidelines suggest discontinuing GLP-1 receptor agonists 1 day prior in patients on daily dosing and 1 week prior in patients on weekly injection dosing (108)

Interestingly, no difference in food intake was observed between wild-type mice treated with the dual incretin GLP-1/GIP coagonist and those treated with the tri-agonist despite the difference in weight loss, and this was found to be due to significantly higher ATP expenditure in tri-agonist-treated diet-induced obese mice