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In LepR-deficient Koletsky rats, the adenovirally induced expression of LepRs in ARC nucleus improves peripheral insulin sensitivity via enhanced suppression of hepatic glucose production, with no change in insulin-stimulated glucose uptake or disposal

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It has not received a marketing authorisation from the MHRA, nor has it been evaluated or recommended by the National Institute for Health and Care Excellence (NICE)

Miralax may be used off-label in younger children, but only under a healthcare providers guidance

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Physiol Genomics (2005) 22:13949