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As a weight-loss tool, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are used in patients with obesity, which is a risk factor for cancers like colorectal and gastrointestinal
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However, DPP-4 inhibitors have not reduced the risk of major adverse cardiovascular events, possibly because potentiation of SDF-1 enhances plaque growth and instability, activates deleterious neurohormonal mechanisms, and promotes cardiac inflammation and fibrosis
