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Any effect on energy expenditure is less well established and should not be assumed

The core problem is quality control

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SURPASS-2 further established tirzepatides superiority over semaglutide in glycemic control and weight management (44)

In some cases, endoscopic evaluation may be necessary to visualize the intestinal mucosa directly and obtain tissue samples

Lipid Outcomes Versus liraglutide, all tirzepatide doses were associated with statistically greater improvements in triglycerides (%), and numerically greater improvements in high-density lipoprotein (HDL, %), LDL (%) and total cholesterol (%)