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This necessitated developing modified GLP-1 agonists resistant to DPP-4 degradation, allowing once-daily or even once-weekly dosing

For this reason, its strongly advised to use a backup birth control method for 4 weeks after starting tirzepatide and after every dose increase

The medication changed everything about eating except the need to eat well

The glucagon component adds a dimension of metabolic activation that the other compounds simply do not possess

The good news is that adaptation at higher doses typically happens faster than the initial adjustment

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