glp-1 friendly foods What do the new 'GLP-1 Friendly' food labels mean? : NPR GLP-1 Friendly Foods High-Protein Small

Metabolic Effects Beyond Weight Loss Both medication types improve metabolic markers, but dual agonists might offer some advantages in certain areas

D., Smith, P., Ferguson, A

Study Population : 1,961 adults without diabetes Average age: 46 years Average baseline BMI: 37.9 Average baseline weight: 231.3 pounds 74.1% female, 25.9% male 76.6% White, 11.6% Black, 7.0% Asian, 4.8% Other Intervention : Semaglutide 2.4 mg subcutaneously once weekly (n=1,306) Placebo subcutaneously once weekly (n=655) Both groups: Individual counseling sessions every 4 weeks promoting 500-calorie deficit and 150 minutes/week physical activity Duration : 68 weeks Primary Outcome - Mean Percentage Weight Loss : Semaglutide: -14.9% (95% CI: -15.3 to -14.5) Placebo: -2.4% (95% CI: -3.0 to -1.8) Difference: -12.4 percentage points (p0.001) Secondary Outcomes - Categorical Weight Loss : 5% weight loss : 86.4% semaglutide vs 31.5% placebo 10% weight loss : 69.1% semaglutide vs 12.0% placebo 15% weight loss : 50.5% semaglutide vs 4.9% placebo 20% weight loss : 32.0% semaglutide vs 1.7% placebo Trial Completion Rates : Semaglutide: 81.7% completed 68 weeks Placebo: 82.0% completed 68 weeks High completion rates suggest good tolerability and participant satisfaction Safety Data : Gastrointestinal adverse events: 74.2% semaglutide vs 47.9% placebo Serious adverse events: 9.8% semaglutide vs 6.4% placebo Discontinuation due to adverse events: 7.0% semaglutide vs 3.1% placebo STEP 2: Diabetes Population Trial Citation : Davies M, et al

Most patients start feeling the appetite-suppressing effects of a GLP-1 within the first few weeks of treatment, with measurable weight loss building over the following months

Those who could become pregnant should talk with their clinician about pregnancy testing, contraception, and the timing around stopping a GLP-1 medication before trying to conceive, since these drugs are not approved for use during pregnancy, Holt says

May help modulate low-grade inflammation associated with metabolic stress and aging