glp 1 for prader willi The effects of glucagon‐like peptide (GLP)‐1 receptor GLP-1 Pipeline Update: May 2025

Liraglutide vs Semaglutide: The Molecular Difference Liraglutide (Saxenda): First-generation GLP-1 agonist for weight loss Approximately 97% amino acid similarity to natural GLP-1 Half-life of approximately 13 hours Requires daily injection to maintain blood levels Semaglutide (Ozempic, Wegovy): Second-generation GLP-1 agonist Modified structure for greater potency and longer action Half-life of approximately 7 days Weekly injection maintains stable blood levels The structural modifications in semaglutide make it bind more effectively to GLP-1 receptors and resist breakdown longer

Furthermore, GLP-1(7-37) had no effect on levels of angiotensin gene expression in the insulinoma cell line and did not change levels of glucagon, prolactin, and corticotropin mRNAs in islet or pituitary cell lines (23)

[DOI] [PubMed] [Google Scholar] 290.Zhang Y., et al

Supplementary information Supplementary Tables (download XLSX Supplementary Tables 115

Apart from aiding weight loss, Semaglutide/GLP-1 also offers additional health benefits

Compared with the other medications, people taking the GLP-1 drugs had a reduced risk for addiction: 18 per cent for alcohol, 14 per cent for cannabis, 20 per cent for both cocaine and nicotine, and 25 per cent for opioids