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PMID: 36899852

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After a reviewing the evidence from non-clinical studies, clinical trials, and data from post-marketing surveillance, The European Medicines Agency (EMA) committee concluded that NAION is associated with use of semaglutide (the active ingredient in Ozempic and Wegovy)

Dose reduction Reducing the semaglutide dose is often the first strategy considered, and for good reason

Indeed, a cluster of molecules related to the serotonergic system has been reported to influence serotonin levels and host metabolism (Table 2)

Clinical studies often combine drug therapy with some lifestyle guidance