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However, we mitigated the potential confounding effect of CAD through the use of MR analysis and by rigorously selecting genetic instruments that were strongly associated with GLP-1RAs, while excluding SNPs associated with CAD and other pleiotropic pathways

Traditional methods focus on calorie control, exercise, and behaviour change, while GLP-1 medications work on a hormonal level to regulate appetite and metabolism

Some of the programs also offer healthy meal delivery services, which some folks may be interested in to help simplify their weight loss tasks

48 In the Tirzepatide as Compared with Semaglutide for the Treatment of Obesity (SURMOUNT-5) trial in adult participants with obesity but without T2DM, tirzepatide (10 mg or 15 mg) achieved greater weight loss compared with semaglutide (1.7 mg or 2.4 mg weekly dose): 20.2% (95% CI 21.4 to 19.1) versus -13.7% (95% CI 14.9 to 12.6) at week 72