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Based on symptoms and signs of distress: Mudd et all in 2020 did a retrospective study with 183 patients presenting to their Emergency Department with ACE inhibitor-induced angioedema of whom 9.5% needed intubation

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In addition, recurrent mutations of EIF1AX and HECTD1 (ubiquitin-transferase activity) and non-synonymous USH2A (development of retina and inner ear) mutations were observed