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--- Here are some potential actions covered in the article for payers and employers to take as a result of this shift: Update formulary tiers and step therapy policies (consider the impact on comorbidities) Support members transitioning off GLP-1s after reaching their goals Create differentiated access pathways based on patient risk profiles Monitor realworld outcomes beyond A1C (cardiovascular, renal, adherence) Model the downstream impact on generics and legacy therapies --- Commercial plans are accelerating GLP-1 uptake and favoring the simplicity of a single therapy

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Heres a glimpse of what I discuss: - The mechanisms behind GLP-1 agonists' ability to promote weight loss - New data on body weight changes after discontinuing the drug - Effects of GLP-1 agonists on lean mass and body composition, and the role of protein and resistance training in preserving muscle - Early indications that GLP-1 agonists may help treat substance abuse disorders - More