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If nausea persists beyond mild intensity after 14 days at the same dose, decrease to the previous dose step (e.g., from 0.75mg to 0.625mg) and hold there for three weeks

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Users often achieve 10-15% of their total body weight reduction during this phase

Substitution of extracellular Na + by NMDG + abolished the glutamine-induced rise in [Ca 2+ ] i (Fig
