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For type 2 diabetes , NICE NG28 recommends continuing GLP-1 treatment only if there is adequate response, defined as HbA1c reduction of at least 11 mmol/mol (1.0%) and weight loss of at least 3% of initial body weight at 6 months
doi: 10.1002/oby.23563
For instance, central administration of GLP-1R agonists increases the ability of insulin to suppress endogenous glucose production (Knauf et al., 2005
That's the point, of course
Moreover, mice receiving GLP-1 monotherapy displayed significantly lower insulin levels compared with mice that were treated with MK-801 alone
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