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Indeed, patients with HHD show a five- to seven-fold increase in IL-17 levels in the dermal inflammatory infiltrates of affected skin [42]

Data extracted from the selected studies included: study design, sample size, participant demographics, diagnostic criteria, intervention details, comparator, duration of treatment, outcome measures, key efficacy and safety results, and limitations

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In its complete response letter, the regulator requested that AstraZeneca improve Ultomiris Risk Evaluation and Mitigation Strategy (REMS) strategy to further validate patients meningococcal vaccination status or prophylactic administration of antibiotics prior to treatment with the C5 complement inhibitor